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Medical Scientist Training Program > Students > Current MSTP Students

Current MSTP Students


All | 2013 | 2014 | 2015 | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023

2019

Sophie Blackburn

Rechel Geiger

Marina Han

Naveen Jasti

Laurel Kelnhofer-Millevolte

Siegen McKellar

Andrew Mullen

Zackari Murphy

Miguel Paredes

Jordan Shaker

Jeremiah Sims

Kevin Thornton

Alexandra Willcox

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Research Highlight

Folate Transporter’s Role in Immunity

Shivam Zaver’s dissertation research in the laboratory of Dr. Joshua Woodward in the Department of Microbiology addresses innate immunity. DNA is ordinarily located in the nucleus of a cell. DNA can be found outside of the nucleus, however, during a bacterial or viral infection. Once detected where it does not belong, DNA stimulates an interferon-mediated immune response, mediated by a cyclic dinucleotide, which functions as a second messenger. How the cyclic dinucleotide crosses the cell membrane had been unknown. Shivam found that the second messenger is taken up by the cell through a folate transporter. Consequently, inflammation can be inhibited by folate. His discovery explains how some anti-inflammatory medications, such as sulfasalazine and methotrexate, achieve their effect and has implications for developing new forms of immunotherapy for cancer and infectious disease.

Shivam's Profile


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