Transcription-Driven Evolution of TB Drug Resistance
Mark Ragheb's dissertation work in Molecular and Cellular Biology at the University of Washington MSTP reflects a continuing passion for research on tuberculosis that began while he was an undergraduate at Harvard. For his Ph.D. research, performed under the supervision of Dr. Houra Merrikh in the Department of Microbiology, Mark developed a highly innovative strategy for blocking antibiotic resistance in tuberculosis by identifying factors contributing to bacterial diversity and inhibiting evolution, itself. His work was multidisciplinary, employing both experimental and computational approaches and highly collaborative, involving contributions from within and outside the institution. His studies commanded attention from the scientific and lay press, such as in The Atlantic (https://www.theatlantic.com/science/archive/2018/11/anti-evolution-drug-vs-antibiotic-resistant-superbugs/575929/).