September 12, 2019
New PLOS Genetics Publication
E-15 MSTP student Anna-Lisa Doebley in the March 2019 issue of PLOS Genetics considers the integrity of germ lines and mechanisms that act to suppress damage to the genomes. The germ line is effectively immortal and capable of creating new “young” offspring. This research indicates that the C. elegans protein phosphatase GSP-2 is critically important…
New Science Signaling Publication
E-14 MSTP student Eli Grunblatt’s latest publication in Science Signaling‘s February 2019 issue explores small cell lung cancer. There has been limited improvement in first-line SCLC treatment in the past 30 years, and no targeted therapies are currently available. The high death rate and lack of treatment options have led the National Cancer Institute to…
July 11, 2019
Dr. Colin Pritchard authors Nature editorial
Dr. Pritchard suggests that names that label certain cancer risk genes as sex- or organ-specific can dissuade people who need to be tested. Simplifying the name for cancer genetic syndromes could save lives.
June 28, 2019
Alex Salter named one of Forbes “30 under 30” in Healthcare
MSTP Student Alex Salter (E12) is investigating how to enhance the efficacy of CAR T-cell therapy, a technique that utilizes synthetic proteins (CARs) to improve the ability of T cells to detect and destroy cancer cells, at Fred Hutchinson Cancer Research Center.
February 12, 2019
New PLOS Pathogens Publication
E-12 MSTP student Heather Machkovech has a publication in January’s issue of PLOS Pathogens. This publication investigates the sites in the mRNAs that initiate protein translation during influenza infection. In particular, it explores whether some of this translation initiates at codons other than the canonical ones used to produce the primary protein product of each…
September 20, 2017
New Blood Publication
E-11 MSTP student Aaron Seo has a Blood publication describing bone marrow failure in 3 unrelated families caused by inherited mutations in the gene encoding thrombopoietin, an important growth factor for blood cell development produced primarily in the liver and kidney. The mutations result in a lack of thrombopoietin in patients’ serum. Though patients do…
New Nature Methods Publication
UW MSTP student Jack Rose (E-10) has a new Nature Methods publication in collaboration with fellow E-11 MSTP student BJ Valente in which they developed two new tools: ciCas9—a rapidly inducible Cas9 construct, and DSB-ddPCR—a method for time-resolved quantification of double strand breaks in DNA. Using these tools, they investigated CRISPR/Cas9 editing kinetics in human…
New Advanced Materials Paper
E-12 UW MSTP student Chris Arakawa (Bioengineering, DeForest Lab) has a new Advanced Materials paper in which he showcases a new way to create blood vessels using lasers and a synthetic light sensitive biomaterial. Using this novel technique and material he successfully has created the world’s smallest artificial human blood vessels to date with complete…
New Nature Neuro Paper
UW MSTP students Madeleine Geisheker (E-12, first author) and Gabe Heymann (E-13, second author) have a new Nature Neuro paper characterizing the properties of missense mutations in those with autism and other neurodevelopment disorders showing these mutations tend to cluster in specific regions important to protein function, and in genes involved in neuronal signaling.
August 2, 2016
Greg Findlay’s Nature Paper
UW MSTP student Greg Findlay (E-12) is co-first author on a new Nature paper. The paper presents a new technique to create hundreds to thousands of targeted mutations in the human genome and assess the consequences of each one in a rapid and cost-effective manner.
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