December 9, 2019
New Science Publication
MSTP student (E-14) Sanjay Srivatsan’s research on massively multiplex chemical transcriptomics at single cell resolution has been published in December’s Science publication. This article explores the use of sci-Plex, which uses ‘nuclear hashing’ to quantify global transcriptional responses to thousands of independent perturbations at single-cell resolution. Their results reveal substantial intercellular heterogeneity in response to specific compounds, commonalities in response to families of compounds, and insight into differential properties within families.