Medical Scientist Training Program

September 12, 2019

New DNA Repair Publication

E-13 MSTP student Mark Ragheb latest publication in DNA Repair explores the role of Mfd in replication-transcription conflicts in bacteria. DNA replication and transcription, a remarkable undertaking, must occur in a timely and accurate fashion in all organisms. This publication explores the conflicts in this process. Conflicts can lead to various detrimental outcomes, including replication fork stalling, double-stranded DNA breaks (DSBs), and mutations. They discuss in detail how different states of RNAP can impact replisome progression, and largely focus on one highly conserved RNAP associated bacterial translocase, Mfd.