New Blood Publication

E-11 MSTP student Aaron Seo has a Blood publication describing bone marrow failure in 3 unrelated families caused by inherited mutations in the gene encoding thrombopoietin, an important growth factor for blood cell development produced primarily in the liver and kidney. The mutations result in a lack of thrombopoietin in patients’ serum. Though patients do not respond to transplant, treatment with a thrombopoietin mimetic was able to improve blood counts across all lineages.